The Emperor of Ice Cream

C hronic Inflammatory Demyelinating Polyneuropathy essays

C hronic Inflammatory Demyelinating Polyneuropathy essays CHRONIC INFLAMMATORY DEMYELINATING POLYNEUROPATHY Chronic inflammatory demyelinating polyneuropathy (CIDP) is a sporadic acquired disorder which may mimic an inherited neuropathy in childhood. In fact, the commonest chronic neuropathy seen in children is a hereditary motor and sensory neuropathy (HMSN) type I. Evidence of familial involvement is perhaps the single most important characteristic in distinguishing hereditary from acquired disorders in children. It is important to recognize the acquired CIDP since it is potentially a treatable disease and its diagnosis may be suggested by clinical, electrophysiological and nerve biopsy features. Chronic inflammatory demyelinating polyneuropathy (CIDP) is distinguished from the more common acute demyelinating neuropathy, the Guillain-Barre syndrome (GBS), chiefly by clinical course and prognosis. On the one hand, both disorders have similar clinical features, and both share the CSF albumin-cytological dissociation and the pathological abnormalities of multi- focal inflammatory segmental demyelination with associated nerve conduction features reflecting demyelination. An autoimmune basis is suspected for both CIDP and GBS. On the other hand, CIDP has a more protracted clinical course, is rarely associated with preceding infections in children and responds to corticosteroid therapy. In addition, CIDP has an association with HLA antigens as well as an association with the M-phenotype of alpha-one antitrypsin deficiency. The clinical course can follow several patterns. The onset is usually gradual but there was around 15% rapid rate of onset in a series of 92 patients. It also showed that 65% have a relapsing course compared to 35% with progressive or monophasic course. There was a significantly earlier age of onset in patients with relapsing disease, a finding similar to that in multiple sclerosis. In fact, some authors have suggested that CIDP syndrome may be the peripheral nervous sys...

Operational Research & the Decision Sciences Essay

Operational Research & the Decision Sciences - Essay Example While this will be based on the latest decision making tools and methods, all available options should be considered as input to the operation research model adopted for a particular case.......................(1) All business organizations would expect their executives to have enhanced decision-making capability to lead the business from the front on a gainful and productive basis. Operation research is the powerful tool to achieve this. While there are many professional tools and software available to help the business leaders for better decision making, Operation research is unique as it considers only the specific inputs and data that is applicable for a particular challenging problem, while considering the best options and information which is most beneficial for the organization. Hence, the operation research professionals customize each solution, that is unique and tailor made for the imposing challenge. When the available choices are many and it is difficult to work on a particular option, the optimization technology is adopted for minimizing the risks involved, eliminating the unworkable options, while finding the best choice available. This relates to the collection of huge data concerned with the imposing challenge; categorize this data into various degrees of risk involving groups, while finding the connected information, about each group. This method helps in comparing the risk management of the data collected and comparing each group This leads to testing of many options and conclusions for reaching the best solution possible...............(2) When a process is not working efficiently due to non decision making ability at the ground level for day to day operations, there is a need to employ operational research techniques for improving the overall efficiency of the effected process, which in turn can result in better functioning of related processes in the operational chain. This will finally help in the improvement